We are grateful to the following GWAS studies, databases and consortia who have kindly made their summary data available:

• ADIPOGen (adiponectin)
• AMDGene (age related macular degeneration)
• Amundadottir et al (pancreatic cancer)
• Baranzini et al (multiple sclerosis)
• C4D (coronary heart disease)
• Capasso et al (Neuroblastoma)
• CARDIoGRAM (coronary heart disease)
• Ciampa et al (prostate cancer)
• CKDGen (chronic kidney disease and renal function)
• Deming et al (protein QTLs)
• dbGAP
• DIAGRAM (type 2 diabetes)
• Duerr et al (Inflammatory bowel disease)
• EGG (birth and child anthropometrics)
• GABRIEL (asthma)
• GCAN (anorexia nervosa)
• GEFOS (bone)
• GIANT (adult anthropometrics)
• GLGC (lipids)
• GPC (personality)
• GTEx consortium (gene expression QTLs)
• GUGC (urate)
• HaemGen (Haemotological and platelet traits)
• Hom et al
• ICBP (blood pressure)
• IGAP (Alzheimer's disease)
• IIBDGC (Inflammatory bowel disease)
• ILCCO (lung cancer)
• IMSGC (multiple sclerosis)
• Kettunen et al (metabolites)
• Kiel et al (bone structure)
• Li et al (Alzheimer disease)
• Li et al (Upper gastrointestinal cancers)
• MAGIC (glycemic markers)
• Maraganore et al (Parkinson's Disease)
• Matarín et al (ischaemic stroke)
• MDACC (melanoma skin cancer)
• Mueller et al (diabetic nephropathy)
• NHGRI-EBI GWAS catalog
• Okada et al (Rheumatoid Arthritis)
• Olfson et al (alcohol dependence)
• Pankratz et al (Parkinson disease)
• PGC (psychiatric diseases)
• Rajaraman et al (glioma)
• ReproGen (Age at Menarche)
• Roederer et al (immune system)
• Shin et al (metabolites)
• Simón-Sánchez et al (Parkinson's Disease)
• Smith et al (bipolar disorder)
• SSGAC (education & cognitive performance)
• Stahl et al (rheumatoid arthritis)
• TAG (smoking)

The majority of data in MR Base is kindly made available for use by many research organisations and consortia .

These terms (Terms) set out the basis on which the University of Bristol, a body incorporated by Royal Charter under number RC000648 having its administrative offices at Senate House, Tyndall Avenue, Bristol BS8 1TH (University) agrees to provide you with access to the MR-Base platform (Platform) and through the Platform summary data from genome-wide association studies (GWAS Data).

1. Licence: The University grants you a non-exclusive, non-transferable revocable licence to access and use the Platform for private or non-commercial research purposes only. If you wish to access and use the Platform for commercial research purposes, please forward your enquiry to mr-base@bristol.ac.uk.

2. Ownership of MR-base: Subject to paragraph 1, nothing in these Terms grants you any right to, or in, any intellectual property rights of any nature (whether existing now or in the future and whether registered or unregistered) in the Platform.

3. Downloading: You agree that you will not attempt to download GWAS Data from the Platform in bulk or otherwise use the Platform in a way that would or might adversely affect the performance or operation of the Platform for other users.

4. Credits: You agree to cite any use of the Platform in the form set out in the “About” tab. You further agree to observe and comply with any notice requiring you to cite the original source of any GWAS Data in your analyses in the form set out in such notice.

5. Ownership of GWAS Data: GWAS Data may be protected by copyright, database rights and other intellectual property rights around the world. Unless otherwise stated in any notice accompanying any particular GWAS Data, all such rights are reserved by the contributor of the GWAS Data and you agree to observe and comply with any specific licence terms specified by such contributors.

6. Identification of data subjects: You agree not to use, combine, manipulate or transform the GWAS Data in any way that would or might enable you to identify any living individual to which the GWAS Data relates, in breach of data protection laws anywhere in the world.

7. Disclaimers: We do not guarantee that (a) the Platform or any GWAS Data will always be available or interrupted; (b) the Platform or any GWAS Data will be accurate, complete, free from errors or omissions or secure or free from bugs or viruses; or (c) that the result of using the Platform or any GWAS Data will be accurate, adequate or fit for any particular purpose (more general information on the principles, assumptions and limitation of Mendelian randomization can be found on the papers recommended in the “About” tab). Where the Platform contains links to other sites or resources provided by third parties, these links are provided for your information only and you acknowledge that we have no control over the content of those sites or resources. All warranties, representations, conditions and all other terms of any kind whatsoever implied by statute or common law, to the fullest extent permitted by applicable, law, excluding from these Terms.

8. Limitation of liability: You assume sole responsibility for the results obtained from the use of the Platform and any GWAS Data and for conclusions drawn from such use. The University shall have no liability for any damage or other loss whatsoever arising out of or in connection with your use of the Platform or any GWAS Data. The University shall not be liable in any circumstances whether in contract, tort (including for negligence), misrepresentation (whether innocent or negligent), restitution or otherwise for any special, indirect or consequential loss, costs, damages, charges or expenses however arising under these Terms including but not limited to loss of funding or loss of opportunity, goodwill or reputation. Nothing in these Terms excludes or limits any liability which cannot be excluded or limited by applicable law.

9. Suspension and termination: The University may, at its sole discretion, suspend, withdraw, discontinue or change all or any part of the Platform (in respect of any single user, group of users or all users of the Platform) without notice and whether or not arising from any breach of these Terms. The University will not be liable to you in such circumstances.

10. Changes to these Terms: The University may revise these Terms at any time by amending this page. Please check this page from time to time to take notice of any changes, as they will be legally binding on you.

11. Governing law and jurisdiction: These Terms and any claims or disputes arising out of or in connection with them (including non-contractual disputes) shall be governed by the laws of England and Wales whose courts shall have exclusive jurisdiction to settle the same.

Please note that when you log on we keep a record of your email address on our servers to a) ensure that you obtain appropriate access to the GWAS database, b) to compile usage statistics that help us keep this project funded and c) to monitor inappropriate or unfair usage. We do NOT log the queries that are being performed, and we do NOT share your email address with anybody else.

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To use two sample MR to estimate the causal effect of an exposure on an outcome, the first step is to identify SNPs that are robustly associated with the exposure. These summary statistics for these SNPs can be taken from a sample from which there is no data on the outcome.

Please provide instruments by choosing from one of the data sources below, or by uploading your own data. You can choose multiple exposures to be analysed, and multiple instruments per exposure.

The MR Base database houses a large collection of summary statistic data from hundreds of GWAS studies. In order to perform two sample MR, the SNPs that were selected for the exposures will be extracted from the outcomes that you select here.

Please select the outcomes that you want to test for being causally influenced by the exposures.

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